| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Matrix metalloproteinase-24 |
|---|
| Ligand | BDBM50365344 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_806651 (CHEMBL1960134) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Brown, MF; Reilly, U; Abramite, JA; Arcari, JT; Oliver, R; Barham, RA; Che, Y; Chen, JM; Collantes, EM; Chung, SW; Desbonnet, C; Doty, J; Doroski, M; Engtrakul, JJ; Harris, TM; Huband, M; Knafels, JD; Leach, KL; Liu, S; Marfat, A; Marra, A; McElroy, E; Melnick, M; Menard, CA; Montgomery, JI; Mullins, L; Noe, MC; O'Donnell, J; Penzien, J; Plummer, MS; Price, LM; Shanmugasundaram, V; Thoma, C; Uccello, DP; Warmus, JS; Wishka, DG Potent inhibitors of LpxC for the treatment of Gram-negative infections. J Med Chem55:914-23 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Matrix metalloproteinase-24 |
|---|
| Name: | Matrix metalloproteinase-24 |
|---|
| Synonyms: | MMP24 | MMP24_HUMAN | MT5MMP |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 73256.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_806651 |
|---|
| Residue: | 645 |
|---|
| Sequence: | MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG
NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI
PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG
ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG
FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM
APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR
PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ
FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL
RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK
GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV
NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
|
|
|
|---|
| BDBM50365344 |
|---|
| n/a |
|---|
| Name | BDBM50365344 |
|---|
| Synonyms: | CHEMBL1956115 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21NO4S |
|---|
| Mol. Mass. | 347.429 |
|---|
| SMILES | C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
