| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 1 |
|---|
| Ligand | BDBM50365426 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_807294 (CHEMBL1960387) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Gentile, G; Merlo, G; Pozzan, A; Bernasconi, G; Bax, B; Bamborough, P; Bridges, A; Carter, P; Neu, M; Yao, G; Brough, C; Cutler, G; Coffin, A; Belyanskaya, S 5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors. Bioorg Med Chem Lett22:1989-94 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PAK 1 |
|---|
| Name: | Serine/threonine-protein kinase PAK 1 |
|---|
| Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 60640.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13153 |
|---|
| Residue: | 545 |
|---|
| Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
|
|
|
|---|
| BDBM50365426 |
|---|
| n/a |
|---|
| Name | BDBM50365426 |
|---|
| Synonyms: | CHEMBL1957085 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15N3O3 |
|---|
| Mol. Mass. | 309.3193 |
|---|
| SMILES | COc1ccc(cc1)-c1ocnc1C(=O)NCc1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
