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TargetRenin
LigandBDBM50365568
Substrate/Competitorn/a
Meas. Tech.ChEMBL_808016 (CHEMBL1961075)
IC50 0.5±n/a nM
Citation Lacombe, PArbour, MAspiotis, RCauchon, EChen, ADubé, DFalgueyret, JPFournier, PAGallant, MGrimm, EHan, YJuteau, HLiu, SMellon, CRamtohul, YSimard, DSt-Jacques, RTsui, GC 3,4-Diarylpiperidines as potent renin inhibitors. Bioorg Med Chem Lett22:1953-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50365568
n/a
NameBDBM50365568
Synonyms:CHEMBL1957795
TypeSmall organic molecule
Emp. Form.C28H30F2N2O2
Mol. Mass.464.5468
SMILESCC(=O)NCCc1ccccc1-c1ccc([C@H]2CNCC[C@]2(O)c2ccc(F)c(F)c2)c(C)c1 |r|
Structure
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