| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 14 |
|---|
| Ligand | BDBM12342 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_807328 (CHEMBL1960508) |
|---|
| Ki | >200000±n/a nM |
|---|
| Citation |  Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II. Bioorg Med Chem Lett22:2182-5 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 14 |
|---|
| Name: | Carbonic anhydrase 14 |
|---|
| Synonyms: | CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37665.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human (cloned) isozyme. |
|---|
| Residue: | 337 |
|---|
| Sequence: | MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD
LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH
LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ
LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG
CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
|
|
|
|---|
| BDBM12342 |
|---|
| n/a |
|---|
| Name | BDBM12342 |
|---|
| Synonyms: | 2H-chromen-2-one | CHEMBL6466 | Coumarin |
|---|
| Type | Natural product |
|---|
| Emp. Form. | C9H6O2 |
|---|
| Mol. Mass. | 146.1427 |
|---|
| SMILES | O=c1ccc2ccccc2o1 |
|---|
| Structure | 
|
|---|
Search and Browse
