| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 8 |
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| Ligand | BDBM4078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_808267 (CHEMBL1961237) |
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| IC50 | 2370±n/a nM |
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| Citation |  Hundsdörfer, C; Hemmerling, HJ; Götz, C; Totzke, F; Bednarski, P; Le Borgne, M; Jose, J Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors. Bioorg Med Chem20:2282-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 8 |
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| Name: | Mitogen-activated protein kinase kinase kinase 8 |
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| Synonyms: | C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 52916.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41279 |
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| Residue: | 467 |
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| Sequence: | MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
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| BDBM4078 |
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| n/a |
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| Name | BDBM4078 |
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| Synonyms: | 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione | CHEMBL6246 | ELLAGIC ACID | Elagic Acid | Ellagic acid (18) | Ellagic acid dihydrate | MLS000069632 | SMR000058244 | cid_5281855 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H6O8 |
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| Mol. Mass. | 302.1926 |
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| SMILES | Oc1cc2c3c(oc(=O)c4cc(O)c(O)c(oc2=O)c34)c1O |
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| Structure | 
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