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TargetD(2) dopamine receptor
LigandBDBM50137972
Substrate/Competitorn/a
Meas. Tech.ChEBML_62880
Ki 8.5±n/a nM
Citation Campiani, GButini, SFattorusso, CCatalanotti, BGemma, SNacci, VMorelli, ECagnotto, AMereghetti, IMennini, TCarli, MMinetti, PDi Cesare, MAMastroianni, DScafetta, NGalletti, BStasi, MACastorina, MPacifici, LVertechy, MDi Serio, SGhirardi, OTinti, OCarminati, P Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. J Med Chem47:143-57 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
D(2) dopamine receptor
Name:D(2) dopamine receptor
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:P61169
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50137972
n/a
NameBDBM50137972
Synonyms:7-Fluoro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f]azulene | CHEMBL366679
TypeSmall organic molecule
Emp. Form.C17H18FN3S
Mol. Mass.315.408
SMILESCN1CCN(CC1)C1=Cn2cccc2Sc2ccc(F)cc12 |t:8|
Structure
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