| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50137976 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_139077 |
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| Ki | 2070±n/a nM |
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| Citation |  Campiani, G; Butini, S; Fattorusso, C; Catalanotti, B; Gemma, S; Nacci, V; Morelli, E; Cagnotto, A; Mereghetti, I; Mennini, T; Carli, M; Minetti, P; Di Cesare, MA; Mastroianni, D; Scafetta, N; Galletti, B; Stasi, MA; Castorina, M; Pacifici, L; Vertechy, M; Di Serio, S; Ghirardi, O; Tinti, O; Carminati, P Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. J Med Chem47:143-57 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50137976 |
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| n/a |
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| Name | BDBM50137976 |
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| Synonyms: | 9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f]azulene | CHEMBL367045 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N3S |
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| Mol. Mass. | 297.418 |
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| SMILES | CN1CCN(CC1)C1=Cn2cccc2Sc2ccccc12 |t:8| |
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| Structure | 
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