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Target5-hydroxytryptamine receptor 2A
LigandBDBM50137976
Substrate/Competitorn/a
Meas. Tech.ChEBML_2306
Ki 1.1±n/a nM
Citation Campiani GButini SFattorusso CCatalanotti BGemma SNacci VMorelli ECagnotto AMereghetti IMennini TCarli MMinetti PDi Cesare MAMastroianni DScafetta NGalletti BStasi MACastorina MPacifici LVertechy MDi Serio SGhirardi OTinti OCarminati P Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. J Med Chem 47:143-57 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 2A
Name:Dopamine D2 receptor and serotonin 2a receptor
Synonyms:5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | HTR2 | HTR2A | Serotonin receptor 2A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52607.65
Organism:Homo sapiens (Human)
Description:n/a
Residue:471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50137976
n/a
NameBDBM50137976
Synonyms:9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f]azulene | CHEMBL367045
TypeSmall organic molecule
Emp. Form.C17H19N3S
Mol. Mass.297.418
SMILESCN1CCN(CC1)C1=Cn2cccc2Sc2ccccc12 |t:8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: