Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50279966 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_196193 (CHEMBL803638) |
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Ki | 2230±n/a nM |
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Citation | Hebel, D; Kirk, K; Kinjo, J; Kovacs, T; Lesiak, K; Balzarini, J; De Clercq, E; Torrence, P Synthesis of a difluoromethylenephosphonate analogue of AZT 5'-triphosphate and its inhibition of HIV-1 reverse transcriptase Bioorg Med Chem Lett1:357-360 (1991) Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50279966 |
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n/a |
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Name | BDBM50279966 |
Synonyms: | Azidothymidine difluoromethylenephosphonate derivative | {[({[3-azido-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphinato]difluoromethyl}phosphonate |
Type | Small organic molecule |
Emp. Form. | C11H12F2N5O12P3 |
Mol. Mass. | 537.1596 |
SMILES | Cc1cn(C2CC(N=[N+]=[N-])C(COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)O2)c(=O)[nH]c1=O |
Structure |
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