Ki Summary

Reaction Details

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Target

Neurotensin receptor type 1

Ligand

BDBM50281809

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_144304

63±n/a nM

Citation

Cain, GA; Christos, TE; Johnson, AL; Pottorf, RS; Confalone, PN; William Tam, S; Schmidt, WK Neurotensin receptor binding and antinociceptive activity for lipophilic N-amido neurotensin(913) analogs Bioorg Med Chem Lett3:2055-2060 (1993) Article

More Info.:

Get all data from this article, Assay Method

Neurotensin receptor type 1

Name:

Neurotensin receptor type 1

Synonyms:

NTR1_RAT | Neurotensin receptor 1 | Ntsr | Ntsr1

Type:

PROTEIN

Mol. Mass.:

47070.64

Organism:

Rattus norvegicus

Description:

ChEMBL_1466612

Residue:

424

Sequence:

MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTD
IYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLA
MPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTL
MSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQV
NTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRV
QALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYV
SSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATR
ETLY

BDBM50281809

n/a

Name

BDBM50281809

Synonyms:

(S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid | CHEMBL8857

Type

Small organic molecule

Emp. Form.

C37H60N6O9

Mol. Mass.

732.9071

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O

Structure