Ki Summary

Reaction Details

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Target

Cholecystokinin receptor type A

Ligand

BDBM50281737

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_47653

350±n/a nM

Citation

Hill, D; Horwell, D; Hunter, J; Kneen, C; Pritchard, M; Suman-Chauhan, N Synthesis of a potent and selective non-peptide CCK-B/gastrin receptor antagonist tritiated ligand. Bioorg Med Chem Lett3:885-888 (1993) Article

More Info.:

Get all data from this article, Assay Method

Cholecystokinin receptor type A

Name:

Cholecystokinin receptor type A

Synonyms:

CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49676.37

Organism:

RAT

Description:

Cholecystokinin central 0 RAT::P30551

Residue:

444

Sequence:

MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP

BDBM50281737

n/a

Name

BDBM50281737

Synonyms:

(R)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-amino-phenyl)-butyric acid | CHEMBL354049 | PD-140376

Type

Small organic molecule

Emp. Form.

C33H40N4O5

Mol. Mass.

572.6945

SMILES

C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(O)=O)Cc1ccc(N)cc1 |wU:1.0,wD:1.13,29.33,TLB:22:17:25:21.23.20,22:21:16.17.18:25,15:16:21.23.22:19.18.25,THB:20:21:16:19.18.25,20:19:16:21.23.22,15:16:25:21.23.20,(3.41,-9.92,;4.74,-10.71,;6.07,-9.95,;6.09,-8.41,;5.19,-7.17,;6.1,-5.93,;7.57,-6.4,;8.89,-5.63,;10.23,-6.4,;10.23,-7.94,;8.89,-8.71,;7.56,-7.94,;3.39,-11.46,;2.06,-10.69,;2.08,-9.15,;.73,-11.44,;-.81,-11.44,;-.62,-13,;-2,-13.53,;-3.42,-13.21,;-4.47,-14.66,;-3,-14.03,;-1.49,-14.43,;-3.21,-12.42,;-2.3,-11.04,;-3.61,-11.69,;6.07,-11.48,;6.05,-13.02,;7.4,-10.71,;8.73,-11.48,;8.73,-13.02,;10.06,-13.79,;10.06,-15.33,;8.73,-14.54,;10.06,-10.71,;11.39,-11.48,;11.39,-13.02,;12.72,-13.79,;14.05,-13.02,;15.38,-13.79,;14.05,-11.46,;12.72,-10.71,)|

Structure