Reaction Details | |||
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Target | Integrin alpha-IIb/beta-3 | ||
Ligand | BDBM50036088 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_218229 (CHEMBL818904) | ||
Ki | 4.5±n/a nM | ||
Citation | Cheng, H; Davis, L; Holl, W; Nichols, A; Hwang, S; Johanson, K; Wong, A Preparation and Properties of a fibrinogen receptor antagonist containing the Arg-Gly-Asp sequence and nitroxide radicals Bioorg Med Chem Lett3:1179-1184 (1993) Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Integrin alpha-IIb/beta-3 | |||
Name: | Integrin alpha-IIb/beta-3 | ||
Synonyms: | Glycoprotein IIb/IIIa | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of EBI is 30109 | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Integrin beta-3 | ||
Synonyms: | CD_antigen=CD61 | GP3A | GPIIIa | ITB3_HUMAN | ITGB3 | Integrin alpha-V/beta-3/alpha-V/beta-5 | Platelet membrane glycoprotein IIIa | ||
Type: | Protein | ||
Mol. Mass.: | 87038.91 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P05106 | ||
Residue: | 788 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Integrin alpha-IIb | ||
Synonyms: | CD_antigen=CD41 | GP2B | GPIIb | GPalpha IIb | Glycoprotein IIb | ITA2B_HUMAN | ITGA2B | ITGAB | Integrin alpha-IIb heavy chain | Integrin alpha-IIb light chain, form 1 | Integrin alpha-IIb light chain, form 2 | Integrin alpha-IIb/beta-3 | Integrin alpha-V/beta-3 and alpha-IIb/beta 3 | Platelet membrane glycoprotein IIb | ||
Type: | Protein | ||
Mol. Mass.: | 113354.85 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08514 | ||
Residue: | 1039 | ||
Sequence: |
| ||
BDBM50036088 | |||
n/a | |||
Name | BDBM50036088 | ||
Synonyms: | CHEMBL18734 | [(6S,13S)-13-(3-Guanidino-propyl)-14-methyl-6,9,12,15-tetraoxo-6,7,8,9,10,11,12,13,14,15-decahydro-5H-20,21-dithia-5,8,11,14-tetraaza-dibenzo[a,e]cycloheptadecen-7-yl]-acetic acid | [(7S,13S)-13-(3-Guanidino-propyl)-14-methyl-6,9,12,15-tetraoxo-6,7,8,9,10,11,12,13,14,15-decahydro-5H-20,21-dithia-5,8,11,14-tetraaza-dibenzo[a,e]cycloheptadecen-7-yl]-acetic acid | [13-(3-Guanidino-propyl)-14-methyl-6,9,12,15-tetraoxo-6,7,8,9,10,11,12,13,14,15-decahydro-5H-20,21-dithia-5,8,11,14-tetraaza-dibenzo[a,e]cycloheptadecen-7-yl]-acetic acid (SK&F 107260) | ||
Type | Small organic molecule | ||
Emp. Form. | C26H31N7O6S2 | ||
Mol. Mass. | 601.698 | ||
SMILES | CN1[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccccc2SSc2ccccc2C1=O | ||
Structure |