| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50285065 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_201928 |
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| IC50 | 1.2±n/a nM |
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| Citation |  Iwasawa, Y; Hayashi, M; Nomoto, T; Shibata, J; Mitsuya, M; Hirota, K; Yonemoto, M; Kamei, T; Miura, K; Tomimoto, K Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase Bioorg Med Chem Lett5:1989-1994 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48114.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1352847 |
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| Residue: | 417 |
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| Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
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| BDBM50285065 |
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| n/a |
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| Name | BDBM50285065 |
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| Synonyms: | (S)-2-{[(1S,2S)-2-Biphenyl-4-yl-3-(3,4-dichloro-phenyl)-1-methyl-propylcarbamoyl]-methyl}-succinic acid | CHEMBL61935 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27Cl2NO5 |
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| Mol. Mass. | 528.424 |
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| SMILES | C[C@H](NC(=O)C[C@@H](CC(O)=O)C(O)=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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