| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 3A/3B |
|---|
| Ligand | BDBM50108392 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_3139 (CHEMBL617981) |
|---|
| Ki | 1.3±n/a nM |
|---|
| Citation |  Lopez-Rodriguez, ML; Morcillo, MJ; Benhamu, B; Riaguas, MD Novel benzimidazole-4-carboxylic acid derivatives as potent and selective 5-HT3 receptor ligands Bioorg Med Chem Lett6:1195-1198 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 3A/3B |
|---|
| Name: | 5-hydroxytryptamine receptor 3A/3B |
|---|
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 2974 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | 5-hydroxytryptamine receptor 3B |
|---|
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50328.78 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | EBI_11885 |
|---|
| Residue: | 437 |
|---|
| Sequence: | MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLC
VHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFV
DVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDID
LGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVV
SLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGV
FFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTE
SPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVL
GLYTVTLCSLWALWSRM
|
|
|
|---|
| Component 2 |
| Name: | 5-hydroxytryptamine receptor 3A |
|---|
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55428.70 |
|---|
| Organism: | RAT |
|---|
| Description: | 5-HT3 HTR3A RAT::P35563 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
|
|
|
|---|
| BDBM50108392 |
|---|
| n/a |
|---|
| Name | BDBM50108392 |
|---|
| Synonyms: | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE | CHEMBL56564 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H20N2O2 |
|---|
| Mol. Mass. | 284.3529 |
|---|
| SMILES | CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1| |
|---|
| Structure | 
|
|---|
Search and Browse
