| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate--cysteine ligase catalytic subunit |
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| Ligand | BDBM50287274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68755 (CHEMBL681832) |
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| Ki | 4950±n/a nM |
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| Citation |  Katoh, M; Hiratake, J; Kato, H; Oda, J Mechanism-based inactivation of E. coli -glutamylcysteine synthetase by phosphinic acid- and sulfoximine-based transition-state analogues Bioorg Med Chem Lett6:1437-1442 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate--cysteine ligase catalytic subunit |
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| Name: | Glutamate--cysteine ligase catalytic subunit |
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| Synonyms: | GCLC | GLCL | GLCLC | GSH1_HUMAN | Gamma-glutamylcysteine synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72759.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_68753 |
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| Residue: | 637 |
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| Sequence: | MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN
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| BDBM50287274 |
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| n/a |
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| Name | BDBM50287274 |
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| Synonyms: | (2S)-2-ammonio-4-[(2-carboxylatobutyl)phosphinato]butanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C9H16NO6P |
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| Mol. Mass. | 265.2013 |
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| SMILES | CCC(CP([O-])(=O)CC[C@H]([NH3+])C([O-])=O)C([O-])=O |
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| Structure | 
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