Ki Summary

Reaction Details

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Target

Endothelin-1 receptor

Ligand

BDBM50287883

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_65818

1300±n/a nM

Citation

Fruh, T; Saika, H; Svensson, L; Pitterna, T; Sakaki, J; Okada, T; Urade, Y; Oda, K; Fujitani, Y; Takimoto, M; Yamamura, T; Inui, T; Makatani, M; Umemura, I; Teno, N; Toh, H; Hayakawa, K; Murata, T IRL 2500: A potent ETB selective endothelin antagonist Bioorg Med Chem Lett6:2323-2328 (1996) Article

More Info.:

Get all data from this article, Assay Method

Endothelin-1 receptor

Name:

Endothelin-1 receptor

Synonyms:

EDNRA | EDNRA_PIG | Endothelin receptor ET-A

Type:

PROTEIN

Mol. Mass.:

48707.29

Organism:

Sus scrofa

Description:

ChEMBL_65803

Residue:

427

Sequence:

METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN

BDBM50287883

n/a

Name

BDBM50287883

Synonyms:

CHEMBL412003 | Suc-Glu-Ala-Gly-Tyr-Phe-Ala-His-Leu-Asp-lle-lle-Trp-COOH

Type

Small organic molecule

Emp. Form.

C74H99N15O21

Mol. Mass.

1534.6658

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

Structure