| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50071431 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65818 |
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| Ki | 11000±n/a nM |
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| Citation |  Fruh, T; Saika, H; Svensson, L; Pitterna, T; Sakaki, J; Okada, T; Urade, Y; Oda, K; Fujitani, Y; Takimoto, M; Yamamura, T; Inui, T; Makatani, M; Umemura, I; Teno, N; Toh, H; Hayakawa, K; Murata, T IRL 2500: A potent ETB selective endothelin antagonist Bioorg Med Chem Lett6:2323-2328 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48707.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_65803 |
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| Residue: | 427 |
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| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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| BDBM50071431 |
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| n/a |
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| Name | BDBM50071431 |
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| Synonyms: | (S)-2-{(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]-3-phenyl-propionylamino}-3-(1H-indol-3-yl)-propionic acid | CHEMBL439759 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31N3O4 |
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| Mol. Mass. | 497.5848 |
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| SMILES | CN([C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)C(=O)c1cc(C)cc(C)c1 |
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| Structure | 
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