| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-B receptor |
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| Ligand | BDBM50071754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143209 |
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| IC50 | 150±n/a nM |
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| Citation |  Eden, J; Hall, M; Higginbottom, M; Horwell, D; Howson, W; Hughes, J; Jordan, R; Lewthwaite, R; Martin, K; McKnight, A; Pinnock, R; Pritchard, M; Suman-Chauhan, N; Williams, S PD 165929 the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist Bioorg Med Chem Lett6:2617-2622 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-B receptor |
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| Name: | Neuromedin-B receptor |
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| Synonyms: | NMB | NMBR_RAT | Neuromedin B receptor | Neuromedin-B receptor | Nmbr |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43540.92 |
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| Organism: | RAT |
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| Description: | NMB 0 RAT::P24053 |
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| Residue: | 390 |
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| Sequence: | MPPRSLPNLSLPTEASESELEPEVWENDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLG
NIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIP
AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAV
FSEVARIGSSDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLI
RSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSL
GHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGQKSYPERSTSYLLSSSAV
RMTSLKSNAKNVVTNSVLLNGHSTKQEIAL
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| BDBM50071754 |
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| n/a |
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| Name | BDBM50071754 |
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| Synonyms: | (S)-2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide | CHEMBL86828 | NMB | Xenopus NMB |
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| Type | Small organic molecule |
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| Emp. Form. | C37H47N5O2 |
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| Mol. Mass. | 593.8014 |
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| SMILES | CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(CCCCC1)c1ccccn1 |
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| Structure | 
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