| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuraminidase |
|---|
| Ligand | BDBM50288445 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_200636 |
|---|
| IC50 | 16±n/a nM |
|---|
| Citation |  Smith, PW; Sollis, SL; Howes, PD; Cherry, PC; Cobley, KN; Taylor, H; Whittington, AR; Scicinski, J; Bethell, RC; Taylor, N; Skarzynski, T; Cleasby, A; Singh, O; Wonacott, A; Varghese, J; Colman, P Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides Bioorg Med Chem Lett6:2931-2936 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuraminidase |
|---|
| Name: | Neuraminidase |
|---|
| Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I34A1 | Neuraminidase | Neuraminidase A |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 50124.14 |
|---|
| Organism: | Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1)) |
|---|
| Description: | P03468 |
|---|
| Residue: | 454 |
|---|
| Sequence: | MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNST
WVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLT
QGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGI
SGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKI
FKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIG
YICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIW
DPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKT
IWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
|
|
|
|---|
| BDBM50288445 |
|---|
| n/a |
|---|
| Name | BDBM50288445 |
|---|
| Synonyms: | (4S,5R,6R)-5-Acetylamino-6-dibutylcarbamoyl-4-guanidino-5,6-dihydro-4H-pyran-2-carboxylic acid | CHEMBL321962 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H31N5O5 |
|---|
| Mol. Mass. | 397.4692 |
|---|
| SMILES | [#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6])-[#6](=O)-[#6@@H]-1-[#8]-[#6](=[#6]-[#6@H](\[#7]=[#6](\[#7])-[#7])-[#6@H]-1-[#7]-[#6](-[#6])=O)-[#6](-[#8])=O |c:13| |
|---|
| Structure | 
|
|---|
Search and Browse
