Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 4

Ligand

BDBM50288593

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_3344

>10000±n/a nM

Citation

Fancelli, D; Caccia, C; Fornaretto, M; McArthur, R; Severino, D; Vaghi, F; Varasi, M Serotoninergic 5-HT3 and 5-HT4 receptor activities of dihydrobenzofuran carboxylic acid derivatives Bioorg Med Chem Lett6:263-266 (1996) Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 4

Name:

5-hydroxytryptamine receptor 4

Synonyms:

5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46117.31

Organism:

RAT

Description:

5-HT4 HTR4 RAT::Q62758

Residue:

406

Sequence:

MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN
STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD
TVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS

BDBM50288593

n/a

Name

BDBM50288593

Synonyms:

2-(2,3-dihydrobenzo[b]furan-7-ylcarboxamido)-(2R)-4-azabicyclo[2.2.2]octane | CHEMBL91841

Type

Small organic molecule

Emp. Form.

C16H20N2O2

Mol. Mass.

272.3422

SMILES

O=C(N[C@H]1CN2CCC1CC2)c1cccc2CCOc12 |wD:3.2,(7.01,-4.9,;8.31,-5.72,;9.68,-5,;9.73,-3.44,;11.11,-2.75,;11.17,-1.2,;9.87,-.37,;8.49,-1.1,;8.43,-2.64,;9.25,-1.45,;9.89,-2.11,;8.25,-7.26,;6.89,-7.97,;6.82,-9.53,;8.13,-10.33,;9.48,-9.62,;10.92,-10.16,;11.9,-8.95,;11.03,-7.65,;9.55,-8.08,)|

Structure