Ki Summary

Reaction Details

Report a problem with these data

Target

Serine protease 1

Ligand

BDBM50133525

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_212727

3000±n/a nM

Citation

Sanderson, PE; Dyer, DL; Naylor-Olsen, AM; Vacca, JP; Gardell, SJ; Dale Lewis, S; Lucas, BJ; Lyle, EA; Lynch, JJ; Mulichak, AM L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor Bioorg Med Chem Lett7:1497-1500 (1997) Article

More Info.:

Get all data from this article, Assay Method

Serine protease 1

Name:

Serine protease 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

26557.80

Organism:

Homo sapiens (Human)

Description:

P07477

Residue:

247

Sequence:

MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS

BDBM50133525

n/a

Name

BDBM50133525

Synonyms:

CHEMBL115643 | N-((trans-4-aminocyclohexyl)methyl)-2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetamide | N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide

Type

Small organic molecule

Emp. Form.

C22H30N4O4S

Mol. Mass.

446.563

SMILES

Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)NC[C@H]1CC[C@H](N)CC1 |wU:24.25,wD:27.29,(9.06,-2.5,;7.71,-3.25,;6.36,-2.48,;5.05,-3.25,;5.05,-4.76,;3.7,-5.53,;2.38,-4.76,;2,-6.25,;2.76,-3.25,;1.04,-4.02,;1.01,-2.48,;-.34,-1.71,;-.37,-.19,;.96,.63,;2.31,-.14,;2.32,-1.68,;6.36,-5.56,;6.36,-7.1,;7.71,-4.79,;9.02,-5.58,;10.36,-4.82,;10.37,-3.28,;11.69,-5.59,;13.03,-4.82,;14.37,-5.61,;15.7,-4.84,;17.03,-5.62,;17.01,-7.16,;18.35,-7.97,;15.66,-7.93,;14.35,-7.15,)|

Structure