Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM50290206

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_58455

1±n/a nM

Citation

Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett7:2403-2408 (1997) Article

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

Cell-surface receptors

Mol. Mass.:

50647.10

Organism:

Homo sapiens (Human)

Description:

P14416

Residue:

443

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

BDBM50290206

n/a

Name

BDBM50290206

Synonyms:

CHEMBL78800 | Thiophene-2-carboxylic acid (4-{2-[4-(2-chloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide

Type

Small organic molecule

Emp. Form.

C23H30ClN3OS

Mol. Mass.

432.022

SMILES

Clc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)c2cccs2)CC1 |wU:13.13,wD:16.20,(14.4,-.17,;15.21,-1.48,;16.74,-1.45,;17.55,-2.76,;16.81,-4.11,;15.27,-4.15,;14.47,-2.83,;12.93,-2.85,;12.2,-4.2,;10.66,-4.23,;9.85,-2.92,;8.31,-2.95,;7.56,-4.29,;6.02,-4.3,;5.23,-5.63,;3.69,-5.63,;2.94,-4.3,;3.69,-2.97,;5.23,-2.97,;1.4,-4.32,;.63,-5.65,;-.91,-5.65,;1.4,-6.98,;2.92,-7.05,;2.78,-9.71,;1.24,-9.62,;.54,-8.27,;10.6,-1.57,;12.14,-1.55,)|

Structure