| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-1 |
|---|
| Ligand | BDBM10355 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_90855 (CHEMBL699291) |
|---|
| IC50 | 2000±n/a nM |
|---|
| Citation |  Bajusz, S; Fauszt, I; Németh, K; Barabás, E; Juhász, A; Patthy, M Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases). Bioorg Med Chem Lett8:1477-82 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-1 |
|---|
| Name: | Caspase-1 |
|---|
| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45154.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29466 |
|---|
| Residue: | 404 |
|---|
| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
|
|
|---|
| BDBM10355 |
|---|
| n/a |
|---|
| Name | BDBM10355 |
|---|
| Synonyms: | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid | Ac-YVAD-CHO | CHEMBL37630 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H32N4O8 |
|---|
| Mol. Mass. | 492.5222 |
|---|
| SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
