Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50070546 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_142731 |
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IC50 | 0.019000±n/a nM |
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Citation | Kubota, H; Okamoto, Y; Fujii, M; Ikeda, K; Takeuchi, M; Shibanuma, T; Isomura, Y Synthesis and NK1 receptor antagonistic activity of (+/-)-1-acyl-3-(3,4- dichlorophenyl)-3-[2-(spiro-substituted piperidin-1'-yl)ethyl]piperidines. Bioorg Med Chem Lett8:1541-6 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 46261.42 |
Organism: | GUINEA PIG |
Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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BDBM50070546 |
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n/a |
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Name | BDBM50070546 |
Synonyms: | 1-(2-{(S)-3-(3,4-Dichloro-phenyl)-1-[2-(3-isopropoxy-phenyl)-acetyl]-piperidin-3-yl}-ethyl)-4-phenyl-1-azonia-bicyclo[2.2.2]octane; chloride | CHEMBL38763 | SR 140333 |
Type | Small organic molecule |
Emp. Form. | C37H45Cl2N2O2 |
Mol. Mass. | 620.671 |
SMILES | CC(C)Oc1cccc(CC(=O)N2CCC[C@@](CC[N+]34CCC(CC3)(CC4)c3ccccc3)(C2)c2ccc(Cl)c(Cl)c2)c1 |
Structure |
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