Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50051007 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63877 |
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IC50 | 110±n/a nM |
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Citation | Mederski, WW; Dorsch, D; Osswald, M; Anzali, S; Christadler, M; Schmitges, CJ; Schelling, P; Wilm, C; Fluck, M Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. Bioorg Med Chem Lett8:1771-6 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_PIG | Endothelin receptor ET-B |
Type: | PROTEIN |
Mol. Mass.: | 49616.89 |
Organism: | Sus scrofa |
Description: | ChEMBL_63872 |
Residue: | 443 |
Sequence: | MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSN
ASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGN
STLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPF
IQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALG
FDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCE
MLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCE
LLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQS
CLKFKANDHGYDNFRSSNKYSSS
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BDBM50051007 |
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n/a |
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Name | BDBM50051007 |
Synonyms: | (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | 4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | A-127722 | CHEMBL9194 |
Type | Small organic molecule |
Emp. Form. | C29H38N2O6 |
Mol. Mass. | 510.6218 |
SMILES | CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1 |
Structure |
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