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TargetPlasmepsin 2
LigandBDBM50071561
Substrate/Competitorn/a
Meas. Tech.ChEBML_154921
Ki 110±n/a nM
Citation Carroll CDPatel HJohnson TOGuo TOrlowski MHe ZMCavallaro CLGuo JOksman AGluzman IYConnelly JChelsky DGoldberg DEDolle RE Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett 8:2315-20 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Plasmepsin 2
Name:Plasmepsin 2
Synonyms:Aspartic hemoglobinase II | PFAPD | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:Enzyme
Mol. Mass.:51482.09
Organism:Plasmodium falciparum
Description:P46925
Residue:453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50071561
n/a
NameBDBM50071561
Synonyms:3-Hydroxy-4-{(2S,3S)-3-methyl-2-[2-(naphthalen-2-yloxy)-acetylamino]-pentanoylamino}-5-phenyl-pentanoic acid butylamide | CHEMBL74974
TypeSmall organic molecule
Emp. Form.C33H43N3O5
Mol. Mass.561.7116
SMILESCCCCNC(=O)CC(O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)COc1ccc2ccccc2c1)[C@@H](C)CC
Structure
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