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TargetPlasmepsin II
LigandBDBM50071557
Substrate/Competitorn/a
Meas. Tech.ChEBML_154921
Ki 5600±n/a nM
Citation Carroll, CDPatel, HJohnson, TOGuo, TOrlowski, MHe, ZMCavallaro, CLGuo, JOksman, AGluzman, IYConnelly, JChelsky, DGoldberg, DEDolle, RE Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett8:2315-20 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Plasmepsin II
Name:Plasmepsin II
Synonyms:Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:Enzyme
Mol. Mass.:51482.09
Organism:Plasmodium falciparum
Description:P46925
Residue:453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50071557
n/a
NameBDBM50071557
Synonyms:3-Hydroxy-6-methyl-4-{(S)-4-methyl-2-[2-(naphthalen-2-yloxy)-acetylamino]-pentanoylamino}-heptanoic acid butylamide | CHEMBL77282
TypeSmall organic molecule
Emp. Form.C30H45N3O5
Mol. Mass.527.6954
SMILESCCCCNC(=O)CC(O)C(CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)COc1ccc2ccccc2c1
Structure
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