| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin II |
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| Ligand | BDBM50071553 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_154921 |
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| Ki | 600±n/a nM |
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| Citation |  Carroll, CD; Patel, H; Johnson, TO; Guo, T; Orlowski, M; He, ZM; Cavallaro, CL; Guo, J; Oksman, A; Gluzman, IY; Connelly, J; Chelsky, D; Goldberg, DE; Dolle, RE Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett8:2315-20 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin II |
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| Name: | Plasmepsin II |
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| Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
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| Type: | Enzyme |
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| Mol. Mass.: | 51482.09 |
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| Organism: | Plasmodium falciparum |
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| Description: | P46925 |
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| Residue: | 453 |
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| Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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| BDBM50071553 |
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| n/a |
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| Name | BDBM50071553 |
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| Synonyms: | 1-({(1S,2S)-1-[1-Benzyl-2-hydroxy-3-(3-phenyl-propylcarbamoyl)-propylcarbamoyl]-2-methyl-butylcarbamoyl}-methyl)-4-phenyl-piperidine-4-carboxylic acid amide | CHEMBL75554 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H53N5O5 |
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| Mol. Mass. | 683.8793 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)CN1CCC(CC1)(C(N)=O)c1ccccc1)C(=O)NC(Cc1ccccc1)C(O)CC(=O)NCCCc1ccccc1 |
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| Structure | 
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