| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gastrin-releasing peptide receptor |
|---|
| Ligand | BDBM50071736 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_39763 |
|---|
| Ki | 33±n/a nM |
|---|
| Citation |  Ashwood, V; Brownhill, V; Higginbottom, M; Horwell, DC; Hughes, J; Lewthwaite, RA; McKnight, AT; Pinnock, RD; Pritchard, MC; Suman-Chauhan, N; Webb, C; Williams, SC PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett8:2589-94 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gastrin-releasing peptide receptor |
|---|
| Name: | Gastrin-releasing peptide receptor |
|---|
| Synonyms: | Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43214.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Bombesin 2 GRPR 0::P30550 |
|---|
| Residue: | 384 |
|---|
| Sequence: | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
|
|
|
|---|
| BDBM50071736 |
|---|
| n/a |
|---|
| Name | BDBM50071736 |
|---|
| Synonyms: | (S)-N-[1-(3,4-Dimethoxy-phenyl)-cyclohexylmethyl]-3-(1H-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide | CHEMBL85400 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H39N5O6 |
|---|
| Mol. Mass. | 613.7034 |
|---|
| SMILES | COc1ccc(cc1OC)C1(CNC(=O)[C@](C)(Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(cc2)[N+]([O-])=O)CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
