| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-B receptor |
|---|
| Ligand | BDBM50071745 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_39622 |
|---|
| Ki | 0.068000±n/a nM |
|---|
| Citation |  Ashwood, V; Brownhill, V; Higginbottom, M; Horwell, DC; Hughes, J; Lewthwaite, RA; McKnight, AT; Pinnock, RD; Pritchard, MC; Suman-Chauhan, N; Webb, C; Williams, SC PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett8:2589-94 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-B receptor |
|---|
| Name: | Neuromedin-B receptor |
|---|
| Synonyms: | Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43447.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Bombesin 1 NMBR 0::P28336 |
|---|
| Residue: | 390 |
|---|
| Sequence: | MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
|
|
|
|---|
| BDBM50071745 |
|---|
| n/a |
|---|
| Name | BDBM50071745 |
|---|
| Synonyms: | CHEMBL403317 | Compound NMB | Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2(Neuromedin B) | NMB |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C52H73N15O12S |
|---|
| Mol. Mass. | 1132.294 |
|---|
| SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
