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TargetGRPR
LigandBDBM50071746
Substrate/Competitorn/a
Meas. Tech.ChEBML_39763
Ki 37±n/a nM
Citation Ashwood VBrownhill VHigginbottom MHorwell DCHughes JLewthwaite RAMcKnight ATPinnock RDPritchard MCSuman-Chauhan NWebb CWilliams SC PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett 8:2589-94 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
GRPR
Name:Gastrin releasing peptide receptor
Synonyms:Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | Gastrin-releasing peptide receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:43214.53
Organism:Homo sapiens (Human)
Description:Bombesin 2 GRPR 0::P30550
Residue:384
Sequence:
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50071746
n/a
NameBDBM50071746
Synonyms:(S)-2-[3-(4-Cyano-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide | CHEMBL327840
TypeSmall organic molecule
Emp. Form.C32H34N6O2
Mol. Mass.534.6514
SMILESC[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(cc1)C#N)C(=O)NCC1(CCCCC1)c1ccccn1
Structure
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