| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50072254 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_216337 (CHEMBL818751) |
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| IC50 | 900±n/a nM |
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| Citation |  Giordani, A; Pevarello, P; Cini, M; Bormetti, R; Greco, F; Toma, S; Speciale, C; Varasi, M 4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase. Bioorg Med Chem Lett8:2907-12 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO_RAT | Kmo |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54371.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1487468 |
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| Residue: | 478 |
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| Sequence: | MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSY
RGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLT
AVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKK
PRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMS
FEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
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| BDBM50072254 |
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| n/a |
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| Name | BDBM50072254 |
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| Synonyms: | (E)-4-(3,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid | CHEMBL98963 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H6Cl2O3 |
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| Mol. Mass. | 245.059 |
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| SMILES | OC(=O)\C=C\C(=O)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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