| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase HRas |
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| Ligand | BDBM50072338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_82665 |
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| IC50 | >300000±n/a nM |
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| Citation |  Baraldi, PG; Cacciari, B; Guiotto, A; Leoni, A; Romagnoli, R; Spalluto, G; Mongelli, N; Howard, PW; Thurston, DE; Bianchi, N; Gambari, R Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid. Bioorg Med Chem Lett8:3019-24 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase HRas |
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| Name: | GTPase HRas |
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| Synonyms: | GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 21293.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01112 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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|
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| BDBM50072338 |
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| n/a |
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| Name | BDBM50072338 |
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| Synonyms: | 3-((S)-7-Methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yloxy)-propionic acid methyl ester | CHEMBL300580 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N2O5 |
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| Mol. Mass. | 332.3511 |
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| SMILES | COC(=O)CCOc1cc2N=C[C@@H]3CCCN3C(=O)c2cc1OC |c:10| |
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| Structure | 
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