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TargetSubstance-P receptor
LigandBDBM50069863
Substrate/Competitorn/a
Meas. Tech.ChEBML_205567
IC50 0.110000±n/a nM
Citation Rosen, TJCoffman, KJMcLean, SCrawford, RTBryce, DKGohda, YTsuchiya, MNagahisa, ANakane, MLowe, JA Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist. Bioorg Med Chem Lett8:281-4 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Substance-P receptor
Name:Substance-P receptor
Synonyms:NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46254.43
Organism:Homo sapiens (Human)
Description:P25103
Residue:407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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  Blast E-value cutoff:
BDBM50069863
n/a
NameBDBM50069863
Synonyms:CHEMBL329007 | N-{4-Methoxy-3-[((2S,3S)-2-phenyl-piperidin-3-ylamino)-methyl]-phenyl}-N-methyl-methanesulfonamide
TypeSmall organic molecule
Emp. Form.C21H29N3O3S
Mol. Mass.403.538
SMILESCOc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)N(C)S(C)(=O)=O
Structure
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