| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50068848 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_103854 |
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| IC50 | 4.8±n/a nM |
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| Citation |  Jeng, AY; Chou, M; Parker, DT Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorg Med Chem Lett8:897-902 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | MMP12_MOUSE | Matrix metalloproteinase 12 | Mme | Mmel | Mmp12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54988.61 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_796155 |
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| Residue: | 473 |
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| Sequence: | MSCTLLKGVCTMKFLMMIVFLQVSACGAAPMNDSEFAEWYLSRFYDYGKDRIPMTKTKTN
RNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPDVQHLRAVPQRSRWMKRYLTY
RIYNYTPDMKREDVDYIFQKAFQVWSDVTPLRFRKLHKDEADIMILFAFGAHGDFNYFDG
KGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLQHSNNPKSIM
YPTYRYLNPSTFRLSADDIRNIQSLYGAPVKPPSLTKPSSPPSTFCHQSLSFDAVTTVGE
KIFFFKDWFFWWKLPGSPATNITSISSIWPSIPSGIQAAYEIESRNQLFLFKDEKYWLIN
NLVPEPHYPRSIYSLGFSASVKKVDAAVFDPLRQKVYFFVDKHYWRYDVRQELMDPAYPK
LISTHFPGIKPKIDAVLYFKRHYYIFQGAYQLEYDPLFRRVTKTLKSTSWFGC
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| BDBM50068848 |
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| n/a |
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| Name | BDBM50068848 |
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| Synonyms: | (2R,4R)-2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-4-methyl-hexanoic acid hydroxyamide | CHEMBL170601 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N2O5S |
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| Mol. Mass. | 420.522 |
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| SMILES | CC[C@@H](C)C[C@@H](N(Cc1ccccc1)S(=O)(=O)c1ccc(OC)cc1)C(=O)NO |
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| Structure | 
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