| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
|---|
| Ligand | BDBM50003359 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_139844 |
|---|
| Ki | 42±n/a nM |
|---|
| Citation |  Sabb, AL; Husbands, GM; Tokolics, J; Stein, RP; Tasse, RP; Boast, CA; Moyer, JA; Abou-Gharbia, M Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling. Bioorg Med Chem Lett9:1895-900 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M1 |
|---|
| Name: | Muscarinic acetylcholine receptor M1 |
|---|
| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51442.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11229 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
|
|
|
|---|
| BDBM50003359 |
|---|
| n/a |
|---|
| Name | BDBM50003359 |
|---|
| Synonyms: | 5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid | 5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine | CHEMBL21536 | CHEMBL73149 | LY 246708 | Xanomeline |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H23N3OS |
|---|
| Mol. Mass. | 281.417 |
|---|
| SMILES | CCCCCCOc1nsnc1C1=CCCN(C)C1 |t:13| |
|---|
| Structure | 
|
|---|
Search and Browse
