| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM50074916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_207865 |
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| Ki | >50000±n/a nM |
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| Citation |  Garrett, GS; McPhail, SJ; Tornheim, K; Correa, PE; McIver, JM Synthesis of potent and selective inhibitors of human plasma kallikrein. Bioorg Med Chem Lett9:301-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM50074916 |
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| n/a |
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| Name | BDBM50074916 |
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| Synonyms: | [(R)-2,2-Dimethyl-1-({(S)-naphthalen-2-yl-[3,3,3-trifluoro-1-(4-guanidino-benzyl)-2-oxo-propylcarbamoyl]-methyl}-carbamoyl)-propyl]-carbamic acid adamantan-1-yl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C40H48F3N6O5 |
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| Mol. Mass. | 749.841 |
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| SMILES | CC(C)(C)[C@@H](NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](C(=O)NC(Cc1ccc(NC(N)=[NH2+])cc1)C(=O)C(F)(F)F)c1ccc2ccccc2c1 |TLB:12:13:17:11.10.16,16:11:18:15.17.14,16:15:18:11.10.12,THB:12:11:17:13.18.14| |
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| Structure | 
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