| Reaction Details |
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 | Report a problem with these data |
| Target | Growth hormone secretagogue receptor type 1 |
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| Ligand | BDBM50083975 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_70348 |
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| IC50 | 48±n/a nM |
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| Citation |  Ye, Z; Gao, Y; Bakshi, RK; Chen, MH; Rohrer, SP; Feighner, SD; Pong, SS; Howard, AD; Blake, A; Birzin, ET; Locco, L; Parmar, RM; Chan, WW; Schaeffer, JM; Smith, RG; Patchett, AA; Nargund, RP Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues. Bioorg Med Chem Lett10:5-8 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth hormone secretagogue receptor type 1 |
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| Name: | Growth hormone secretagogue receptor type 1 |
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| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
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| Type: | Receptor |
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| Mol. Mass.: | 41334.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
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| Residue: | 366 |
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| Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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| BDBM50083975 |
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| n/a |
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| Name | BDBM50083975 |
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| Synonyms: | CHEMBL536706 | N-(5-Amino-pentyl)-2-(4-oxo-2-phenethyl-6-phenyl-4H-quinazolin-3-yl)-acetamide; hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N4O2 |
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| Mol. Mass. | 468.59 |
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| SMILES | NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(cc2c1=O)-c1ccccc1 |
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| Structure | 
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