| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Chymotrypsin-C |
|---|
| Ligand | BDBM50090226 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_197814 |
|---|
| Ki | 7550±n/a nM |
|---|
| Citation |  Baettig, U; Brown, L; Brundish, D; Dell, C; Furzer, A; Garman, S; Janus, D; Kane, PD; Smith, G; Walker, CV; Cockcroft, X; Ambler, J; Mitchelson, A; Talbot, MD; Tweed, M; Wills, N The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position. Bioorg Med Chem Lett10:1563-6 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Chymotrypsin-C |
|---|
| Name: | Chymotrypsin-C |
|---|
| Synonyms: | CLCR | CTRC | CTRC_HUMAN | Caldecrin | Chymotrypsin | Chymotrypsin C | Chymotrypsin-C |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29487.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99895 |
|---|
| Residue: | 268 |
|---|
| Sequence: | MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCG
GTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRN
DIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPV
VDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSR
RGCNTRKKPVVYTRVSAYIDWINEKMQL
|
|
|
|---|
| BDBM50090226 |
|---|
| n/a |
|---|
| Name | BDBM50090226 |
|---|
| Synonyms: | 3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {(S)-1-benzothiazol-2-ylmethyl-2-[4-(2-hydroxy-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide | CHEMBL290025 | MD805 Analogue |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H34N4O4S2 |
|---|
| Mol. Mass. | 542.713 |
|---|
| SMILES | CC1CNc2c(C1)cccc2S(=O)(=O)N[C@@H](Cc1nc2ccccc2s1)C(=O)N1CCC(CCO)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
