| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil collagenase |
|---|
| Ligand | BDBM50100087 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_105212 |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Baxter, AD; Bhogal, R; Bird, J; Keily, JF; Manallack, DT; Montana, JG; Owen, DA; Pitt, WR; Watson, RJ; Wills, RE Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors. Bioorg Med Chem Lett11:1465-8 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil collagenase |
|---|
| Name: | Neutrophil collagenase |
|---|
| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53413.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22894 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
|
|
|
|---|
| BDBM50100087 |
|---|
| n/a |
|---|
| Name | BDBM50100087 |
|---|
| Synonyms: | 5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfonylmethyl]-pentanoic acid hydroxyamide; hydrochloride | CHEMBL542088 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H24N2O5S |
|---|
| Mol. Mass. | 452.523 |
|---|
| SMILES | ONC(=O)C(CCCc1ccccc1)CS(=O)(=O)c1ccc(cc1)C(=O)c1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
