| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Ligand | BDBM50174558 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205216 (CHEMBL816490) |
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| IC50 | >123000±n/a nM |
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| Citation |  Fan, G; Mar, W; Park, MK; Choi, EW; Kim, K; Kim, S A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. Bioorg Med Chem Lett11:2361-3 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29472.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18405 |
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| Residue: | 259 |
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| Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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| BDBM50174558 |
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| n/a |
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| Name | BDBM50174558 |
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| Synonyms: | 7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chromen-2-one | CHEMBL51628 | Coumarin derivative, 3a | beta-umbelliferone | hydrangin | skimmetin | umbelliferone |
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| Type | Small organic molecule |
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| Emp. Form. | C9H6O3 |
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| Mol. Mass. | 162.1421 |
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| SMILES | Oc1ccc2ccc(=O)oc2c1 |
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| Structure | 
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