Reaction Details |
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Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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Ligand | BDBM50103878 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_205216 |
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IC50 | 820±n/a nM |
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Citation | Fan, G; Mar, W; Park, MK; Choi, EW; Kim, K; Kim, S A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. Bioorg Med Chem Lett11:2361-3 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
Type: | Enzyme |
Mol. Mass.: | 29472.80 |
Organism: | Homo sapiens (Human) |
Description: | P18405 |
Residue: | 259 |
Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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BDBM50103878 |
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n/a |
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Name | BDBM50103878 |
Synonyms: | Acetic acid 8-allyl-2-oxo-2H-chromen-7-yl ester | CHEMBL77169 |
Type | Small organic molecule |
Emp. Form. | C14H12O4 |
Mol. Mass. | 244.2427 |
SMILES | CC(=O)Oc1ccc2ccc(=O)oc2c1CC=C |
Structure |
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