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TargetPlasminogen activator inhibitor 1
LigandBDBM50104502
Substrate/Competitorn/a
Meas. Tech.ChEMBL_155617 (CHEMBL766352)
IC50 260±n/a nM
Citation Folkes, ARoe, MBSohal, SGolec, JFaint, RBrooks, TCharlton, P Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett11:2589-92 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Plasminogen activator inhibitor 1
Name:Plasminogen activator inhibitor 1
Synonyms:Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:Enzyme
Mol. Mass.:45064.00
Organism:Homo sapiens (Human)
Description:P05121
Residue:402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50104502
n/a
NameBDBM50104502
Synonyms:8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid | CHEMBL87654
TypeSmall organic molecule
Emp. Form.C31H31N3O6S
Mol. Mass.573.659
SMILESOC(=O)CCCCCCCOc1ccc(\C=c2/[nH]c(=O)\c(=C\c3ccc(NC(=O)c4cccs4)cc3)[nH]c2=O)cc1
Structure
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