Ki Summary

Reaction Details

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Target

Genome polyprotein

Ligand

BDBM50096411

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_143618 (CHEMBL751678)

30±n/a nM

Citation

Johansson, A; Hubatsch, I; Akerblom, E; Lindeberg, G; Winiwarter, S; Danielson, UH; Hallberg, A Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett11:203-6 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Genome polyprotein

Name:

Genome polyprotein

Synonyms:

Hepatitis C virus NS3 protease/helicase | Hepatitis C virus serine protease, NS3/NS4A

Type:

Protein

Mol. Mass.:

67067.41

Organism:

Hepatitis C virus

Description:

A3EZI9

Residue:

631

Sequence:

APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAG
TRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRG
DGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMR
SPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSI
LGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIK
GGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLT
HIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLY
RLGAVQNEITLTHPITKYIMTCMSADLEVVT

BDBM50096411

n/a

Name

BDBM50096411

Synonyms:

AcAsp-Glu-Dif-Ile-Cha-Cys | CHEMBL61390

Type

Small organic molecule

Emp. Form.

C44H60N6O12S

Mol. Mass.

897.045

SMILES

CC[C@@H](C)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@H](CS)C(O)=O

Structure