Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetRAF proto-oncogene serine/threonine-protein kinase
LigandBDBM50105599
Substrate/Competitorn/a
Meas. Tech.ChEBML_163037
IC50 6000±n/a nM
Citation Smith, RABarbosa, JBlum, CLBobko, MACaringal, YVDally, RJohnson, JSKatz, MEKennure, NKingery-Wood, JLee, WLowinger, TBLyons, JMarsh, VRogers, DHSwartz, SWalling, TWild, H Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach. Bioorg Med Chem Lett11:2775-8 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase
Name:RAF proto-oncogene serine/threonine-protein kinase
Synonyms:C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:Serine/threonine-protein kinase
Mol. Mass.:73082.52
Organism:Homo sapiens (Human)
Description:P04049
Residue:648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50105599
n/a
NameBDBM50105599
Synonyms:5-Bromomethyl-3-(3-p-tolyl-ureido)-thiophene-2-carboxylic acid methyl ester | CHEMBL96383 | methyl 5-(bromomethyl)-3-(3-p-tolylureido)thiophene-2-carboxylate
TypeSmall organic molecule
Emp. Form.C15H15BrN2O3S
Mol. Mass.383.26
SMILESCOC(=O)c1sc(CBr)cc1NC(=O)Nc1ccc(C)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: