Reaction Details |
| Report a problem with these data |
Target | RAF proto-oncogene serine/threonine-protein kinase |
---|
Ligand | BDBM50105619 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_163037 |
---|
IC50 | 540±n/a nM |
---|
Citation | Smith, RA; Barbosa, J; Blum, CL; Bobko, MA; Caringal, YV; Dally, R; Johnson, JS; Katz, ME; Kennure, N; Kingery-Wood, J; Lee, W; Lowinger, TB; Lyons, J; Marsh, V; Rogers, DH; Swartz, S; Walling, T; Wild, H Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach. Bioorg Med Chem Lett11:2775-8 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
RAF proto-oncogene serine/threonine-protein kinase |
---|
Name: | RAF proto-oncogene serine/threonine-protein kinase |
Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 73082.52 |
Organism: | Homo sapiens (Human) |
Description: | P04049 |
Residue: | 648 |
Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
BDBM50105619 |
---|
n/a |
---|
Name | BDBM50105619 |
Synonyms: | 1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl)-urea | 1-(5-tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)urea | CHEMBL94487 |
Type | Small organic molecule |
Emp. Form. | C20H21N3O3 |
Mol. Mass. | 351.399 |
SMILES | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1 |
Structure |
|