Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50097918 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_61824 |
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IC50 | 32±n/a nM |
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Citation | Simoni, D; Roberti, M; Rondanin, R; Baruchello, R; Rossi, M; Invidiata, FP; Merighi, S; Varani, K; Gessi, S; Borea, PA; Marino, S; Cavallini, S; Bianchi, C; Siniscalchi, A Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter. Bioorg Med Chem Lett11:823-7 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68749.45 |
Organism: | Rattus norvegicus (rat) |
Description: | P23977 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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BDBM50097918 |
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n/a |
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Name | BDBM50097918 |
Synonyms: | (3R,6R)-3-[(4-Chloro-phenyl)-phenyl-methoxy]-6-methoxy-8-methyl-8-aza-bicyclo[3.2.1]octane | CHEMBL168814 |
Type | Small organic molecule |
Emp. Form. | C22H26ClNO2 |
Mol. Mass. | 371.9 |
SMILES | CO[C@@H]1CC2C[C@H](CC1N2C)OC(c1ccccc1)c1ccc(Cl)cc1 |TLB:11:6:9:3.2,THB:1:2:9:7.5.6,10:9:3.2:7.5.6| |
Structure |
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