| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 2 |
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| Ligand | BDBM50050513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54693 (CHEMBL669548) |
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| Ki | 125±n/a nM |
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| Citation |  Senten, K; Van der Veken, P; Bal, G; De Meester, I; Lambeir, AM; Scharpé, S; Bauvois, B; Haemers, A; Augustyns, K Development of potent and selective dipeptidyl peptidase II inhibitors. Bioorg Med Chem Lett12:2825-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 2 |
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| Name: | Dipeptidyl peptidase 2 |
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| Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
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| Type: | Protein |
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| Mol. Mass.: | 54339.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UHL4 |
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| Residue: | 492 |
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| Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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| BDBM50050513 |
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| n/a |
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| Name | BDBM50050513 |
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| Synonyms: | (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid | (S)-2-Amino-1-((R)-2-dihydroxyboron-pyrrolidin-1-yl)-3-methyl-butan-1-one | (S)-2-Amino-3-methyl-2-boronic acid-1-pyrrolidin-1-yl-butan-1-one | Boronic acid derivative | CHEMBL67279 | Ketopyrrolidine derivative | Pyrrolidine derivative | US11096924, DASH-inhibitors 2504 C | US11504364, Compound Val-boroPro | US11559537, Compound 2054-Val-boro-Pro | US11707539, Compound 2054 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H19BN2O3 |
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| Mol. Mass. | 214.07 |
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| SMILES | CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r| |
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| Structure | 
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