Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50120157 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_145476 |
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Ki | 3312±n/a nM |
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Citation | Wu, WL; Caplen, MA; Domalski, MS; Zhang, H; Fawzi, A; Burnett, DA Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands. Bioorg Med Chem Lett12:3157-60 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50120157 |
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n/a |
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Name | BDBM50120157 |
Synonyms: | C-[(R)-C-((R)-1-Benzhydryl-azetidin-2-yl)-C-(3-trifluoromethyl-phenyl)]-methylamine | CHEMBL317479 |
Type | Small organic molecule |
Emp. Form. | C24H23F3N2 |
Mol. Mass. | 396.448 |
SMILES | N[C@@H]([C@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F |
Structure |
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