Reaction Details |
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Target | Nociceptin receptor |
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Ligand | BDBM50120169 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_145007 |
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Ki | 2593±n/a nM |
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Citation | Wu, WL; Caplen, MA; Domalski, MS; Zhang, H; Fawzi, A; Burnett, DA Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands. Bioorg Med Chem Lett12:3157-60 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Nociceptin receptor |
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Name: | Nociceptin receptor |
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40702.87 |
Organism: | Homo sapiens (Human) |
Description: | P41146 |
Residue: | 370 |
Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM50120169 |
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n/a |
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Name | BDBM50120169 |
Synonyms: | C-[(R)-C-{(S)-1-[Bis-(3-trifluoromethyl-phenyl)-methyl]-azetidin-2-yl}-C-(3-chloro-phenyl)]-methylamine | CHEMBL320061 |
Type | Small organic molecule |
Emp. Form. | C25H21ClF6N2 |
Mol. Mass. | 498.891 |
SMILES | N[C@@H]([C@@H]1CCN1C(c1cccc(c1)C(F)(F)F)c1cccc(c1)C(F)(F)F)c1cccc(Cl)c1 |
Structure |
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